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1

Permeability and Leaching Properties of Recycled Concrete Aggregate as an Emerging Material in Civil Engineering

Głuchowski, Andrzej, Sas, Wojciech, Dzięcioł, Justyna, Soból, Emil, Szymański, Alojzy

Journal:

Applied Sciences

Year:

2018

Language:

english

File:

PDF, 3.64 MB

english, 2018

2

Theramal, mechanical, optical, and morphologic changes in bovine nucleus pulposus induced by Nd:YAG (λ = 1.32 μm) laser irradiation

Joon Y. Choi, B. Samuel Tanenbaum, Thomas E. Milner, Xavier V. Dao, J. Stuart Nelson, Emil N. Sobol, Brian J.F. Wong

Journal:

Lasers in Surgery and Medicine

Year:

2001

Language:

english

File:

PDF, 228 KB

english, 2001

3

Effects of laser irradiation on collagen organization in chemically induced degenerative annulus fibrosus of lumbar intervertebral disc

Natalia Ignatieva, Olga Zakharkina, Irina Andreeva, Emil Sobol, Vladislav Kamensky, Valery Lunin

Journal:

Lasers in Surgery and Medicine

Year:

2008

Language:

english

File:

PDF, 260 KB

english, 2008

4

Laser reshaping of costal cartilage for transplantation

Olga I. Baum, Yulia M. Soshnikova, Emil N. Sobol, Andrey Ya. Korneychuk, Mariya V. Obrezkova, Valeriy M. Svistushkin, Oxana K. Timofeeva, Valeriy V. Lunin

Journal:

Lasers in Surgery and Medicine

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

5

Oxygen mass transfer in the decomposition and synthesis of high-temperature superconductors

Journal:

Physica B: Condensed Matter

Year:

1991

Language:

english

File:

PDF, 142 KB

english, 1991

6

Epiglottis reshaping using CO2laser: A minimally invasive technique and its potent applications

Constantinos Bourolias, Jiannis Hajiioannou, Emil Sobol, George Velegrakis, Emmanuel Helidonis

Journal:

Head & Face Medicine

Year:

2008

Language:

english

File:

PDF, 355 KB

english, 2008

7

Feedback controlled laser system for safe and efficient reshaping of nasal cartilage

Emil Sobol, Alexander Sviridov, Natalia Vorobieva, Valery Svistushkin

Journal:

Head & Neck Oncology

Year:

2010

Language:

english

File:

PDF, 161 KB

english, 2010

8

Shaping of nasal septal cartilage with the carbon dioxide laser—a preliminary report of an experimental study

A. Helidonis, Emil Sobol, G. Velegrakis, J. Bizakis

Journal:

Lasers in Medical Science

Year:

1994

Language:

english

File:

PDF, 739 KB

english, 1994

9

IR Laser and Heat-induced Changes in Annulus Fibrosus Collagen Structure

Natalia Yu. Ignatieva, Olga L. Zakharkina, Irina V. Andreeva, Emil N. Sobol, Vladislav A. Kamensky, Alexey V. Myakov, Sergey V. Averkiev, Valery V. Lunin

Journal:

Photochemistry and Photobiology

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

10

Proteoglycan Synthesis in Porcine Nasal Cartilage Grafts Following Nd:YAG (λ= 1.32 μm) Laser-Mediated Reshaping

Brian J. F. Wong, Thomas E. Milner, Hong K. Kim, Ken Chao, Chung-Ho Sun, Emil N. Sobol, J. Stuart Nelson

Journal:

Photochemistry and Photobiology

Year:

2000

Language:

english

File:

PDF, 144 KB

english, 2000

11

Temperature alterations of infrared light absorption by cartilage and cornea under free-electron laser radiation

Sobol, Emil N., Sviridov, Alexander P., Kitai, Moishe S., Edwards, Glenn S.

Journal:

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

12

S271 – The Use of Erbium Doped Glass Fiber Laser in Septoplasty

Emmanuel P. Prokopakis, Constantinos Bourolias, George Velegrakis, Emil Sobol, Emmanuel Helidonis

Journal:

Otolaryngology - Head and Neck Surgery

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

13

Laser shaping of composite cartilage grafts

Emmanuel Helidonis, Emil Sobol, George Kavvalos, John Bizakis, Panayotis Christodoulou, George Velegrakis, John Segas, Victor Bagratashvili

Journal:

American Journal of Otolaryngology

Year:

1993

Language:

english

File:

PDF, 615 KB

english, 1993

14

A thermoanalytical study of cartilaginous tissues

Natalia Yu. Ignat’eva, Valery V. Lunin, Alla F. Majorova, Svetlana N. Mudretsova, Victor N. Bagratashvili, Emil N. Sobol, Alexander P. Sviridov

Journal:

Mendeleev Communications

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

15

SPIE Proceedings [SPIE BiOS Europe '95 - Barcelona, Spain (Tuesday 12 September 1995)] Medical Applications of Lasers III - Synthesis of new sulfonated mono- and diphthalocyanines d- and f-elements and perspectives of their application for plastic surgery

Tomilova, Larisa G., Podgaetsky, Vitaly M., Dyumaev, Kirill, Omelchenko, Alexander I., Sviridov, Alexander P., Sobol, Emil N., Bown, Stephen G., Geschwind, Herbert J., Hibst, Raimund, Laffitte, Freder

Year:

1996

Language:

english

File:

PDF, 157 KB

english, 1996

16

SPIE Proceedings [SPIE Europto Biomedical Optics '93 - Budapest, Hungary (Sunday 29 August 1993)] Laser Interaction with Hard and Soft Tissue - Infrared laser ablation of hard tissue

Serafetinides, Alexander A., Makropoulou, Mersini I., Tsikrikas, G. N., Helidonis, Emmanuel S., Kavvalos, George, Sobol, Emil N., van Gemert, Martin J. C., Steiner, Rudolf W., Svaasand, Lars O., Albre

Year:

1994

Language:

english

File:

PDF, 865 KB

english, 1994

17

SPIE Proceedings [SPIE SPIE BiOS - San Francisco, California, USA (Saturday 2 February 2013)] Colloidal Nanocrystals for Biomedical Applications VIII - Nanoparticles for diagnostics and laser medical treatment of cartilage in orthopaedics

Baum, O. I., Parak, Wolfgang J., Osinski, Marek, Soshnikova, Yu. M., Omelchenko, A. I., Yamamoto, Kenji, Sobol, Emil

Year:

2013

Language:

english

File:

PDF, 496 KB

english, 2013

18

SPIE Proceedings [SPIE SPIE BiOS - San Francisco, California, USA (Saturday 22 January 2011)] Optical Interactions with Tissue and Cells XXII - Optical methods for diagnostics and feedback control in laser-induced regeneration of spine disc and joint cartilages

Sobol, Emil, Jansen, E. Duco, Thomas, Robert J., Sviridov, Alexander, Omeltchenko, Alexander, Baum, Olga, Baskov, Andrey, Borchshenko, Igor, Golubev, Vladimir, Baskov, Vladimir

Year:

2011

Language:

english

File:

PDF, 1.82 MB

english, 2011

19

Starch-modified magnetite nanoparticles for impregnation into cartilage

Soshnikova, Yulia M., Roman, Svetlana G., Chebotareva, Natalia A., Baum, Olga I., Obrezkova, Mariya V., Gillis, Richard B., Harding, Stephen E., Sobol, Emil N., Lunin, Valeriy V.

Journal:

Journal of Nanoparticle Research

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

20

Laser Reshaping of Cartilage

Sobol, Emil, Sviridov, Alexander, Omel’chenko, Alexander, Bagratashvili, Victor, Kitai, Moishe, Harding, Stephen E., Jones, Nicholas, Jumel, Kornelia, Mertig, Michael, Pompe, Wolfgang, Ovchinnikov, Yu

Journal:

Biotechnology and Genetic Engineering Reviews

Year:

2000

Language:

english

File:

PDF, 2.28 MB

english, 2000

21

Microstructural changes in sclera under thermo-mechanical effect of 1.56 µm laser radiation increasing transscleral humor outflow

Baum, Olga I., Sobol, Emil N., Bolshunov, Andrey V., Fedorov, Anatoly A., Khomchik, Olga V., Omelchenko, Alexander I., Shcherbakov, Evgenii M.

Journal:

Lasers in Surgery and Medicine

Year:

2014

Language:

english

File:

PDF, 488 KB

english, 2014

22

Laser radiation effect on chondrocytes and intercellular matrix of costal and articular cartilage impregnated with magnetite nanoparticles

Soshnikova, Yulia M., Shekhter, Anatoly B., Baum, Olga I., Shcherbakov, Evgeniy M., Omelchenko, Alexander I., Lunin, Valeriy V., Sobol, Emil N.

Journal:

Lasers in Surgery and Medicine

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

23

Laser-induced regeneration of cartilage

Sobol, Emil, Shekhter, Anatoly, Guller, Anna, Baum, Olga, Baskov, Andrey

Journal:

Journal of Biomedical Optics

Year:

2011

Language:

english

File:

PDF, 671 KB

english, 2011

24

SPIE Proceedings [SPIE BiOS 2000 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 22 January 2000)] Biomedical Applications of Free-Electron Lasers - Alterations of absorption coefficient of tissue water as a result of the heating under the IR-FEL radiation with different wavelengths

Sobol, Emil N., Sviridov, Alexander P., Kitai, Moishe S., Gilligan, Jonathan M., Edwards, Glenn S., Edwards, Glenn S., Sutherland, John C.

Year:

2000

Language:

english

File:

PDF, 495 KB

english, 2000

25

SPIE Proceedings [SPIE International Symposium on Biomedical Optics - San Jose, CA (Saturday 19 January 2002)] Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII - Cartilage reshaping under nonablative laser radiation: research and clinical applications in ENT

Sobol, Emil N., Ovchinnikov, Yuriy M., Svistushkin, Valeriy M., Bagratashvili, Victor N., Sviridov, Alexander P., Omelchenko, Alexander I., Vorobjeva, Natalia N., Shekhter, Anatoliy B., Bartels, Kenne

Year:

2002

Language:

english

File:

PDF, 99 KB

english, 2002

26

Optical characteristics of the cornea and sclera and their alterations under the effect of nondestructive 1.56-μm laser radiation

Yuzhakov, Aleksey V., Sviridov, Alexander P., Baum, Olga I., Shcherbakov, Evgenii M., Sobol, Emil N.

Journal:

Journal of Biomedical Optics

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

27

SPIE Proceedings [SPIE Photonics West '96 - San Jose, CA (Saturday 27 January 1996)] Laser-Tissue Interaction VII - Stress relaxation and cartilage shaping under laser radiation

Sobol, Emil N., Sviridov, Alexander P., Bagratashvili, Victor N., Omelchenko, Alexander I., Ovchinnikov, Yuriy M., Shekhter, Anatoliy B., Downes, S., Howdle, Steven, Jones, Nicholas, Lowe, J., Jacques

Year:

1996

Language:

english

File:

PDF, 386 KB

english, 1996

28

Time-resolved, light scattering measurements of cartilage and cornea denaturation due to free electron laser radiation

Sobol, Emil, Sviridov, Alexander, Kitai, Moishe, Gilligan, Jonathan M., Tolk, Norman H., Edwards, Glenn S.

Journal:

Journal of Biomedical Optics

Year:

2003

Language:

english

File:

PDF, 152 KB

english, 2003

29

SPIE Proceedings [SPIE BiOS - San Francisco, California (Saturday 23 January 2010)] Photonic Therapeutics and Diagnostics VI - Feedback controlled laser system for safe and efficient reshaping of nasal cartilage

Kollias, Nikiforos, Sobol, Emil, Sviridov, Alexander, Choi, Bernard, Zeng, Haishan, Svistushkin, Valery, Vorobieva, Natalia, Malek, Reza S., Wong, Brian J., Ilgner, Justus F. R., Gregory, Kenton W., T

Year:

2010

Language:

english

File:

PDF, 2.41 MB

english, 2010

30

Hybrid optoacoustic and ultrasound biomicroscopy monitors’ laser-induced tissue modifications and magnetite nanoparticle impregnation

Estrada, Héctor, Sobol, Emil, Baum, Olga, Razansky, Daniel

Journal:

Laser Physics Letters

Year:

2014

Language:

english

File:

PDF, 195 KB

english, 2014

31

SPIE Proceedings [SPIE BiOS 2000 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 22 January 2000)] Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical - Kinetics of water transfer and stress relaxation in cartilage heated with 1.56-μm fiber laser

Bagratashvili, Victor N., Bagratashvili, Nodar V., Sviridov, Alexander P., Sobol, Emil N., Omelchenko, Alexander I., Tsypina, Svetlana I., Gapontsev, Valentin P., Samartsev, Igor E., Feldchtein, Felix

Year:

2000

Language:

english

File:

PDF, 969 KB

english, 2000

32

SPIE Proceedings [SPIE SPIE BiOS - San Francisco, California, United States (Saturday 7 February 2015)] Optical Interactions with Tissue and Cells XXVI - Laser-induced formation of micro-pores in the tissues for cartilage repair and treatment of glaucoma

Jansen, E. Duco, Sobol, Emil, Baum, Olga, Shnirelman, Alexander

Year:

2015

Language:

english

File:

PDF, 727 KB

english, 2015

33

SPIE Proceedings [SPIE Photonics Europe - Strasbourg, France (Monday 7 April 2008)] Optical and Digital Image Processing - Imaging of laser-induced thermo-elastic stress in biotissues with shadowgraph

Schelkens, Peter, Omelchenko, Alexander I., Sobol, Emil N., Ebrahimi, Touradj, Cristóbal, Gabriel, Truchetet, Frédéric

Year:

2008

Language:

english

File:

PDF, 1002 KB

english, 2008

34

SPIE Proceedings [SPIE Saratov Fall Meeting 2001 - Saratov, Russia (Tuesday 2 October 2001)] Saratov Fall Meeting 2001: Optical Technologies in Biophysics and Medicine III - Generation of radicals in hard biological tissues under the action of laser radiation

Sviridov, Alexander P., Bagratashvili, Victor N., Sobol, Emil N., Omelchenko, Alexander I., Lunina, Elena V., Zhitnev, Yurii N., Markaryan, Galina L., Lunin, Valerii V., Tuchin, Valery V.

Year:

2002

Language:

english

File:

PDF, 210 KB

english, 2002

35

SPIE Proceedings [SPIE BiOS Europe '95 - Barcelona, Spain (Tuesday 12 September 1995)] Medical Applications of Lasers III - Cartilage reshaping with holmium laser

Sobol, Emil N., Bagratashvili, Victor N., Sviridov, Alexander P., Omelchenko, Alexander I., Kitai, Moishe S., Jones, Nicholas, Zenger, V., Nasedkin, Alexy N., Isaev, M., Karlov, V., Shekhter, Anatoliy

Year:

1996

Language:

english

File:

PDF, 159 KB

english, 1996

36

SPIE Proceedings [SPIE BiOS '98 International Biomedical Optics Symposium - San Jose, CA (Tuesday 27 January 1998)] Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII - Critical temperature transitions in laser-mediated cartilage reshaping

Wong, Brian J., Milner, Thomas E., Kim, Hong H., Telenkov, Sergey A., Chew, Clifford, Kuo, Timothy C., Smithies, Derek J., Sobol, Emil N., Nelson, J. Stuart, Anderson, R. Rox, Bartels, Kenneth E., Bas

Year:

1998

Language:

english

File:

PDF, 636 KB

english, 1998

37

SPIE Proceedings [SPIE BiOS '98 International Biomedical Optics Symposium - San Jose, CA (Tuesday 27 January 1998)] Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII - Feedback-controlled cartilage reshaping with an Nd:YAG laser: effects of pH variation

Chew, Clifford, Wong, Brian J., Milner, Thomas E., Kim, Hong H., Gomez, Alessandra, Nelson, J. Stuart, Sobol, Emil N., Anderson, R. Rox, Bartels, Kenneth E., Bass, Lawrence S., Garrett, C. Gaelyn, Gre

Year:

1998

Language:

english

File:

PDF, 724 KB

english, 1998

38

SPIE Proceedings [SPIE BiOS '99 International Biomedical Optics Symposium - San Jose, CA (Saturday 23 January 1999)] Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX - In-vivo study and histological examination of laser reshaping of cartilage

Sviridov, Alexander P., Sobol, Emil N., Bagratashvili, Victor N., Omelchenko, Alexander I., Ovchinnikov, Yuriy M., Shekhter, Anatoliy B., Svistushkin, Valeriy M., Shinaev, Andrei A., Nikiforova, G., J

Year:

1999

Language:

english

File:

PDF, 1.91 MB

english, 1999

39

SPIE Proceedings [SPIE BiOS '97, Part of Photonics West - San Jose, CA (Saturday 8 February 1997)] Laser-Tissue Interaction VIII - Mechanism of laser-induced stress relaxation in cartilage

Sobol, Emil N., Sviridov, Alexander P., Omelchenko, Alexander I., Bagratashvili, Victor N., Bagratashvili, Nodar V., Popov, Vladimir K., Jacques, Steven L.

Year:

1997

Language:

english

File:

PDF, 124 KB

english, 1997

40

SPIE Proceedings [SPIE Temp Symposium Entry - Smolyan, Bulgaria (Monday 1 September 2003)] Eighth International Conference on Laser and Laser Information Technologies - Transport of aqueous solutions in laser-irradiated biological tissues

Omel'chenko, A. I., Panchenko, Vladislav Y., Sabotinov, Nikola V., Sobol, Emil N., Bagratashvili, Victor N., Ignatieva, Natalia Y., Tarasov, M. V., Lunin, Valerii V.

Year:

2003

Language:

english

File:

PDF, 157 KB

english, 2003

41

SPIE Proceedings [SPIE LAMILADIS '91: International Workshop--Laser Microtechnology and Laser Diagnostics of Surfaces - Chernovstsy, Ukraine (Tuesday 16 April 1991)] LAMILADIS '91 Intl Workshop: Laser Microtechnology and Laser Diagnostics of Surfaces - Action of powerful laser radiation on 1-2-3 superconducting thin films and bulk materials

Zherikhin, Alexander N., Bagratashvili, Victor N., Burimov, Vladimir N., Sobol, Emil N., Shubnii, G. Y., Sviridov, Alexander P., Koroteev, Nikolai I., Panchenko, Vladislav Y.

Year:

1992

Language:

english

File:

PDF, 285 KB

english, 1992

42

SPIE Proceedings [SPIE ICONO '98: Laser Spectroscopy and Optical Diagnostics--Novel Trends and Applications in Laser Chemistry, Biophysics, and Biomedicine - Moscow, Russia (Monday 29 June 1998)] ICONO '98: Laser Spectroscopy and Optical Diagnostics: Novel Trends and Applications in Laser Chemistry, Biophysics, and Biomedicine - Acoustic control of laser shaping of cartilage

Bagratashvili, Nodar V., Dmitriev, A. K., Omelchenko, Alexander I., Sobol, Emil N., Chikishev, Andrey Y., Zadkov, Victor N., Zheltikov, Alexei M.

Year:

1999

Language:

english

File:

PDF, 1.04 MB

english, 1999

43

SPIE Proceedings [SPIE Saratov Fall Meeting 2000 - Saratov, Russia (Thursday 18 January 2001)] Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II - Dynamics of hydrated mucopolysaccharides in cartilaginous tissues treated by laser radiation

Omelchenko, Alexander I., Sobol, Emil N., Ignatieva, Natalia Y., Lunin, Valerii V., Jumel, Kornelia, Harding, Stephen E., Jones, Nicholas, Tuchin, Valery V.

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

44

SPIE Proceedings [SPIE BiOS 2000 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 22 January 2000)] Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical - Effect of partial denaturation on Nd:YAG-laser-mediated stress relaxation of porcine septal cartilage

Kuo, Timothy C., Kim, Hong K., Milner, Thomas E., Nelson, J. Stuart, Sobol, Emil N., Wong, Brian J., Duncan, Donald D., Hollinger, Jeffrey O., Jacques, Steven L.

Year:

2000

Language:

english

File:

PDF, 540 KB

english, 2000

45

SPIE Proceedings [SPIE BiOS 2001 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 20 January 2001)] Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI - Cartilage reshaping: an overview of the state of the art

Karamzadeh, Amir M., Sobol, Emil N., Rasouli, Alexandre, Nelson, J. Stuart, Milner, Thomas E., Wong, Brian J., Anderson, R. Rox, Bartels, Kenneth E., Bass, Lawrence S., Garrett, C. Gaelyn, Gregory, Ke

Year:

2001

Language:

english

File:

PDF, 57 KB

english, 2001

46

SPIE Proceedings [SPIE Europto Biomedical Optics '93 - Budapest, Hungary (Sunday 29 August 1993)] Dental Applications of Lasers - Mechanisms of laser ablation in solid biological tissues

Sobol, Emil N., Sviridov, Alexander P., Bagratashvili, Victor N., Altshuler, Gregory B., Hibst, Raimund

Year:

1993

Language:

english

File:

PDF, 663 KB

english, 1993

47

SPIE Proceedings [SPIE 1st Intl School on Laser Surface Microprocessing - Tashkent, Russian Federation (Monday 30 October 1989)] 1st Intl School on Laser Surface Microprocessing - Limiting role of the mass transfer of gases in laser thermochemical reactions on the surface of solids

Sobol, Emil N., Boyd, Ian W., Konov, Vitali I., Luk'yanchuk, Boris S.

Year:

1990

Language:

english

File:

PDF, 428 KB

english, 1990

48

SPIE Proceedings [SPIE BiOS 2000 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 22 January 2000)] Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical - Hydrodynamic study of the behavior of chondroitin sulphate under nondestructive laser irradiation of cartilage

Sobol, Emil N., Omelchenko, Alexander I., Sviridov, Alexander P., Harding, Stephen E., Jumel, Kornelia, Jones, Nicholas, Duncan, Donald D., Hollinger, Jeffrey O., Jacques, Steven L.

Year:

2000

Language:

english

File:

PDF, 202 KB

english, 2000

49

SPIE Proceedings [SPIE BiOS '99 International Biomedical Optics Symposium - San Jose, CA (Saturday 23 January 1999)] Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical - Effect of wavelength on threshold and kinetics of tissue denaturation under laser radiation

Sobol, Emil N., Sviridov, Alexander P., Kitai, Moishe S., Gilligan, Jonathan M., Tolk, Norman H., Edwards, Glenn S., Jacques, Steven L., Mueller, Gerhard J., Roggan, Andre, Sliney, David H.

Year:

1999

Language:

english

File:

PDF, 793 KB

english, 1999

50

SPIE Proceedings [SPIE BiOS 2000 The International Symposium on Biomedical Optics - San Jose, CA (Saturday 22 January 2000)] Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X - Laser reshaping of nasal septum cartilage: clinical results for 40 patients

Sobol, Emil N., Sviridov, Alexander P., Bagratashvili, Victor N., Omelchenko, Alexander I., Ovchinnikov, Yuriy M., Shekhter, Anatoliy B., Svistushkin, Valeriy M., Shinaev, Alexander N., Anderson, R. R

Year:

2000

Language:

english

File:

PDF, 605 KB

english, 2000